mercredi 15 décembre 2010

Fetal hemoglobin screening in whole blood and in plasma of cancer patients.

Wolk M, Kieselstein M, Ben-Dor CG, Brufman G.

Tel-Hai Hospital for Chronic Diseases, Hadassah University Hospital, Jerusalem, Israel.

Abstract

Fetal hemoglobin (HbF) screening was performed on 296 cancer patients. In almost 80% of the patients with active disease (n = 197) and 35-60% of those with inactive disease (n = 99), the concentration of HbF in the blood was above the normal range. Among patients with metastatic breast carcinoma (n = 27), 89% had a high HbF concentration. The HbF level was significantly higher (p less than 0.001) in patients with active disease than in those with inactive disease. There is evidence of an ectopic production of HbF into the plasma of patients, but it will be necessary to develop a method for the prevention of hemolysis in order to establish this claim.

PMID: 1705048 [PubMed - indexed for MEDLINE]

http://content.karger.com/ProdukteDB/produkte.asp?Doi=217687

Contacts Auteur

Wolk Moshe Dr, rue Tarsish 14, Ma'ale Adumim 90610 (Israël)

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